Beatrice Restore

Volume Restoration & Wrinkle Correction · Collagen Biostimulation

A PDLLA biostimulatory filler for facial volume loss and moderate-to-severe wrinkles such as the nasolabial folds. By stimulating collagen regeneration, it progressively restores tissue volume and reduces wrinkles.

Collagen-regeneration driven — naturally restores tissue volume and improves wrinkles such as the nasolabial folds
Autologous collagen rebuild — longer-lasting results
Uniform microspheres — stable, durable results with low nodule risk

Content 260 mg

Particle Size 25–50 μm

Presentation Vial

Store below 30 °C · ambient transport

Full Specifications

Technical Data at a Glance.

Composition	PDLLA microspheres, carboxymethylcellulose sodium (CMC)
Content	260 mg per vial
Microsphere Size	25–50 μm
Presentation	Vial (lyophilised powder)
Indications	For filling moderate-to-severe wrinkles such as the nasolabial folds, and for improving volume deficiency in the cheek area.
Duration	12–18 months
Storage & Transport	Store below 30 °C at ambient temperature; transport at ambient temperature

Diagram showing PDLLA microsphere biodegradation and collagen regeneration after deep dermal or subcutaneous injection

Mechanism of Action

Following deep dermal or subcutaneous injection, PDLLA microspheres gradually degrade and activate fibroblasts, promoting the regeneration of Type I and III collagen and elastin. This progressively restores facial tissue volume while improving wrinkles and skin elasticity.

Microscopy comparison of amorphous PDLLA microspheres with semi-crystalline PLLA and PCL

Technical Advantage

Compared with PLLA and PCL, PDLLA microspheres have an amorphous structure that offers superior flexibility and resistance to brittle fracture. This allows them to adapt more effectively to dynamic facial tissue movement, supporting a more natural tissue feel and filling performance.

Clinical Case

Before & After

Real patient photography from a Beatrice Restore treatment — drag the divider to compare.

After — Beatrice Restore clinical case: nasolabial folds

Before — Beatrice Restore clinical case: nasolabial folds

Before After

Nasolabial Fold Volume Restoration

A Beatrice Restore treatment for the nasolabial folds, using PDLLA microspheres reconstituted with water for injection.

SubjectFemale · 26 years
RegionNasolabial folds
ProductBeatrice Restore
Dosage260 mg, reconstituted with water for injection

Illustrative clinical case — individual results may vary.

Clinical Evidence

Measured Results.

At 12 months post-treatment, the effective improvement rate for moderate-to-severe nasolabial fold wrinkles reached 81.52%.

81.52%

12-Month Efficacy — Nasolabial Folds

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