PDLLA Collagen Stimulating Filler

The Next-Generation Solution for Clinics and Distributors.

Collagen regeneration is reshaping the aesthetic industry — a paradigm shift from “filling” to “regeneration,” with results that build naturally over time.

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3D skin cross-section showing collagen regeneration in the dermis

The Paradigm Shift

Beyond HA Fillers.
Why Collagen Regeneration Is Reshaping the Aesthetic Industry.

Traditional HA fillers correct volume but are metabolized over time, requiring repeat injections. Repeated treatments at the same site can stretch tissue and lead to an “overfilled,” swollen appearance.

Collagen-stimulating fillers are the core of next-generation materials. PDLLA microspheres activate fibroblasts, shifting the industry from “filling” to “regeneration” — the body rebuilds its own collagen, naturally.

New collagen integrates naturally and is not metabolized away.

Results build gradually — optimal at 2 to 8 months.

Smooths depressions and wrinkles; improves texture and firmness.

Higher satisfaction, word-of-mouth, and clinic margins.

PDLLA Material Science

Why Amorphous PDLLA Matters

Compared with PLLA and PCL, PDLLA microspheres have an amorphous structure that offers superior flexibility and resistance to brittle fracture. This allows them to adapt more effectively to dynamic facial tissue movement, supporting a more natural tissue feel and filling performance.

Microscopy comparison of PDLLA, PLLA, and PCL structures — SEM and Polarized Light Microscopy Comparison of PDLLA, PLLA and PCL

Two Products, One Proven Technology

Two Products, Two Applications.

The same EQUISPHERE core technology, engineered for two clinical territories — face and body.

01 Facial Volume Restoration & Wrinkle Correction

Beatrice Restore

A PDLLA collagen stimulating filler for mid-to-deep facial volume loss and moderate to severe wrinkles, especially nasolabial folds. EQUISPHERE emulsification technology delivers highly uniform microspheres for predictable distribution, consistent collagen stimulation, and minimized nodule risk.

Product FormLyophilized Powder
Microsphere Size25–50 μm
Specification260 mg
Duration12–18 months

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02 Body Volume Filling & Contouring

Beatrice Reshape

A body contouring filler extending the same PDLLA collagen regeneration technology to the chest, buttocks, and shoulders. Larger microspheres and higher active content meet the greater volume demands of body areas, progressively building a naturally fuller appearance.

Product FormLyophilized Powder
Microsphere Size50–90 μm
Specification520 mg
Duration12–18 months

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Product Comparison

Specifications at a Glance

Compare the two PDLLA fillers side by side — specification, particle size, injection layer and duration — to match the right product to each treatment area.

Beatrice Restore

Beatrice Reshape

Specification 260 mg 520 mg

Main Ingredients PDLLA microspheres, CMC PDLLA microspheres, CMC

Particle Size 25–50 μm 50–90 μm

Injection Layer Deep dermis / subcutaneous Subcutaneous / supraperiosteal

Duration 12–18 months 12–18 months

Treatment Focus Volume restoration & wrinkle correction (collagen biostimulation) Body volume restoration & contour remodeling (collagen biostimulation)

Clinical Evidence & Support

The Beatrice Difference.

Clinical data is the most direct sales tool: an 81.52% improvement rate and a duration lasting 12 to 18+ months. These figures help you win purchasing decisions from clinic clients.

Beatrice Restore and Reshape were developed in collaboration with leading aesthetic physicians, designed for real-world clinical success. The efficacy of PDLLA does not happen automatically. It depends heavily on the practitioner’s skill and experience, from reconstitution technique to injection method.

Improvement Rate 81.52%

Result Duration 12–18 months

Partner with Beatrice

Seize the Regenerative Aesthetics Opportunity.

As a PDLLA filler wholesale supplier and trusted partner for aesthetic filler distributors worldwide, we offer more than just products. From dermal filler wholesale to full regenerative treatment systems, we provide a one-stop solution covering both facial and body applications, enabling your clinic clients to transition from traditional fillers to regenerative treatments with comprehensive support in technology, training, and clinical backing.

Contact us today to request product samples, clinical data packages, or registration support. Let us shape the future of the aesthetic industry together.

Facial & body application coverage
Technology, training & clinical backing
Samples, clinical data & registration support